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The chronic inflammatory state, driven by the secretion of tumor necrosis factor (TNF) and other pro-inflammatory cytokines, disrupts insulin signaling pathways, causing insulin resistance

Insulin and IGF-1 signaling GLP-1 medications improve insulin sensitivity, which is one of their major metabolic benefits

Brand-name tirzepatide (sold as Mounjaro for diabetes or Zepbound for weight loss) costs $1,000-1,200/month at retail

One of their effects is to slow down the rate at which food moves through the stomach to the small intestines

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70 in native IGF-1) These modifications make LR3 resistant to insulin-like growth factor binding proteins (IGFBPs) , allowing it to remain biologically active for up to 2030 hours in circulation