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Finally, excessive glucose flux through the hexosamine pathway leads to UDP-GlcNAc accumulation and subsequent O-GlcNAcylation of serine/threonine residues on antioxidant enzymes, like SOD, reducing their activity (Paneque et al., 2023)

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ACS Nano 9, 2377 (2015).CrossRefGoogle ScholarPubMed Forman, H.J., Zhang, H., and Rinna, A.: Glutathione: Overview of its protective roles, measurement, and biosynthesis

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