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( H ) On the GLP-1R, TZP is a partial agonist 51% stimulation (5.2, 3) with an EC 50 of 0.617 nM (0.190, 3) versus GLP-1(7-36) of 1.63 nM (0.21, 26)

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[53] Tirzepatide's benefits for the treatment of adult participants with type 2 diabetes were primarily evaluated in five clinical trials