The sensitivity does not improve after several weeks on the same dose

1 Introduction The prevalence of type 2 diabetes mellitus (T2DM) has been on the rise globally in recent years, with data from the International Diabetes Federation (IDF) showing that there will be 783.2 million people (12.2%) living with diabetes by 2045 ( Standards of Care in Diabetes the addition of GLP-1RAs and/or SGLT2 inhibitors (SGLT2i) to the treatment plan for patients with T2DM who have been diagnosed with or are at high risk of atherosclerotic cardiovascular disease (ASCVD) ( However, the occurrence of gastrointestinal side effects (GISEs) has challenged the application of GLP-1RAs, which were clinically characterized by symptoms such as nausea (42.23%), vomiting (21.90%), diarrhea (21.93%), and constipation (8.41%) ( 2 Methods 2.1 Research design 2.1.1 Study participants and data sources The data used in the study were derived from the healthcare big data platform and the electronic medical record system of the First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital)

Practicing good sleep hygiene, such as maintaining a consistent sleep schedule and creating a comfortable sleep environment, can help alleviate these issues
Patients can choose from injectable or oral options
This is already a rare condition in the US, estimated around 4 to 10 cases per 100,000 people per year , and the risk increases with factors like age and conditions like type 2 diabetes
It is crucial not to adjust your medication without consulting your doctor