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The problem is cumulative

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The table below puts them side by side on the points that matter most to dosing decisions

Overall, these data are encouraging that novel weight-loss medications are effective at reducing body weight and they are also effective at improving many of the cardiometabolic complications of obesity including hypertension, Type 2 diabetes, and dyslipidemia, among others

But it also reported complete weight regain after two years in: It takes a lot of effort to keep that weight off once you stop taking a GLP-1, says Dr

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