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Based on current advancements in oxidative stress research in breast cancer, we propose several innovative therapeutic approaches targeting the ROSPCD network for future development: (1) Oxidative stress-directed small-molecule drugs: Natural compounds such as curcumin can induce apoptosis by triggering mitochondrial ROS bursts and DNA damage while enhancing ferroptosis sensitivity through GPX4 inhibition

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doi: 10.3390/ijms22115717

Y., Chiang, J

If the previous beliefs and protocols cannot be proven safe or effective with the new information available, then we MUST re-evaluate and reconfigure our beliefs and protocols to maximize safety and efficacy

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