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Extra weight increases mechanical stress on the knee, and "visceral adipose tissue secretes adipocytokines and other soluble mediators that increase pain." Felson added that the trial's findings are similar to those from a 2023 study that examined the effects of GLP-1 receptor agonists on adults who had both type 2 diabetes and knee osteoarthritis

This suggests that increasing or decreasing GIP may both enhance how well GLP-1-based drugs work, which Dr

Potential reproductive or systemic consequences have not been well studied, but theoretical risks include changes to hormonal feedback, timing of ovulation, and unintended effects on sperm or embryo development

Novo Nordisk currently sells liraglutide under the brand name Victoza

At his heaviest, in college, he says he weighed 300 pounds

Who is a good candidate for this therapy