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In addition, using the SwissADME software, additional properties were evaluated, including gastrointestinal absorption (GI a), bloodbrain barrier permeability (BBB p), potential inhibition or substrate activity for Pglycoprotein (Pgp), as well as inhibition of the main CYP450 isoforms, specifically 1A2, 2C9, 2C19, 2D6, and 3A4

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Increased tryptophan metabolism can lead to a shift toward the KYN pathway (76)

TCs exposure leads to apoptosis both and in several organs such as lymphoid organs, hematopoietic tissues, liver, intestinal crypts, bone marrow and thymus

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