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In laboratory adipocyte cultures, the peptide has been observed to stimulate lipolysis the enzymatic breakdown of stored triglycerides into free fatty acids and glycerol while simultaneously inhibiting lipogenesis, the re-esterification of fatty acids back into storage triglyceride

Several GDF-15 agonists are undergoing early phase clinical trials including NNC0247-0829 and JNJ-9090/CIN-109

Patients and clinicians should maintain clear communication regarding symptom severity and trajectory

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