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The ventricular septum and the left ventricular posterior wall were not thick

Additional observed toxic mechanisms included loss of MMP, upregulation of the proapoptotic protein Bcl-2-associated X protein (BAX), and downregulation of antiapoptotic markers such as B-cell lymphoma 2 (Bcl-2), poly ADP ribose polymerase (PARP), and caspase-3 [134]

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Serotonin can in turn be converted into melatonin in the brain

Natalizumab, an anti-4-integrin antibody that blocks leukocyte migration to the brain, is also currently under clinical investigation for drug-resistant epilepsy, with some successful cases reported in Rasmussens encephalitis [360, 361]