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Methods Animals All animals were kept on a mixed genetic background (C57BL/6J;129)

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In the PI3K/Akt/mTOR pathway, receptor autophosphorylation recruits and activates phosphoinositide 3-kinase (PI3K), which phosphorylates membrane phospholipids to generate PIP3

This dual-mechanism approach is investigated for its ability to preserve natural HPA-axis feedback while achieving greater GH/IGF-1 output than either peptide alone