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Furthermore, transforming growth factor- 1 (TGF1), released by macrophages, modulates the expression of SLC7A11 via the Smad pathway

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While semaglutide focuses on one pathway, tirzepatide is a dual-action agonist , meaning it activates two different hormone receptors, not just one

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Wnt5a activats Wnt/PCP pathway, upregulating Ras-related C3 botulinum toxin substrate 1(Rac), which can activate JNK, thus aggravating IR in adipose tissue