While a fibrotic matrix initially contributes to tissue repair, after injury, chronic and persistent kidney damage in the development of CKD leads to uncontrolled fibrotic matrix deposition, resulting in reduced blood supply, destruction of normal organ structure, and eventual glomerulosclerosis, renal tubular atrophy, and interstitial fibrosis [9, 10]
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The resulting extract contains primarily water-soluble organosulfur compounds, such as SAC and SAMC (see Figure 3 ) (142)
