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This three-pronged approach is what makes its weight loss numbers so much higher than previous generation compounds
Supply cannibalisation NHS England and the MHRA have both raised concerns that off-label Ozempic prescribing for weight loss creates supply problems for T2D patients who depend on Ozempic clinically
Cole JB, Florez JC
The peptide's 7-day half-life was designed specifically to forgive timing variationuse that flexibility instead of fighting it
While that doesnt mean injections are the right choice for everyone, it does highlight the importance of education, reassurance and giving patients options that feel manageable for them. Jason Murphy, Head of Pharmacy at Chemist4U The pill: the alternative weve been waiting for
Jeffrey Flier, former Dean at Harvard Medical School, writes in STAT on How Pfizer ended up passing on my GLP-1 work back in the early 90s. Flier kicks off with Despite extremely promising results, Pfizer, the major funder of the work in alliance with California Biotechnology, abandoned the effort around 1991 after mistakenly concluding that the GLP-1 therapeutic approach was not worth continuing. He states that he is not trying to take credit for the GLP-1 market, rather that the story offers valuable lessons on drug development for pharmaceutical companies, researchers, and the general public alike. The article describes the early stages of drug development and testing from 1987, with Pfizer against an injectable GLP-1 version, and a focus on a way to deliver GLP-1 via transnasal, transcutaneous, or oral administration
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