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Because it's a fatty acid ester, it may not be fungal acne safe since the Malassezia yeast can utilize it as a nutrient source

A large randomized trial in older adults found no effect of EPA and DHA on cognitive function, and the broader trial record shows little benefit in cognitively healthy people or in established Alzheimers, with a possible signal in early cognitive impairment and in people who do not carry APOE4

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When caffeine dosages were reduced to a moderate level (56 mg/kg), ergogenic benefits were maintained, and negative effects and physiological reactions were also reduced but not completely abolished [35]