glp-1 for chronic pain drugs calm inflammation beyond diabetes and weight loss Advances in GLP-1 receptor agonists

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Oral F.n translocate to the intestine by resisting the acidic environment at pH 1.5 owing to the presence of erucic acid in its cell membrane, which is regulated by FnFabM, increasing its colonization efficiency in the stomach and jejunum of mice (Li et al., 2025)

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Semaglutide, a GLP-1RA, mitigates seizure severity and cognitive impairment through the inhibition of the lipopolysaccharide (LPS)- and nigericin-induced NLRP3 inflammasome pathway, reducing lactate dehydrogenase (LDH) release by microglial cells [53]

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