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Source: Phase 3 TRIUMPH-4 trial (68 weeks, 445 participants) Nausea is the most common side effect overall and usually the worst during the first few weeks and during dose increases

We strongly advise against it for multi-use vials

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However, at two weeks from the booster dose of 50 g, the anti-Delta antibody levels rose to the same level as anti-D614G antibodies had risen at 28 days from the second dose

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To address these challenges, various formulation strategies have been developed