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In the early stages of knee osteoarthritis, conservative therapy (physiotherapy, movement exercises, muscle building, pain therapy with medication) is the first step

Food intake was not impacted, and any observable side effects or toxicity were negligible to the point where they should not be taken seriously

In the second phase, 240 subjects with type 2 diabetes were treated with a placebo

10.1089/ars.2006.8.1329 177

The article below reports a federal advisory-committee proceeding and explains the regulatory framework around it