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3,5,7,8,16 Many cardiac causes, both arrhythmic and structural, have a genetic component, underscoring the value of a thorough family history focused on early cardiac death and inherited cardiac conditions

Energetically favorable literally means that it has a more negative Gibbs free energy, which typically means that the protein is more compact and makes more interactions with itself, like in the rough sketch of a protein on the right side of Figure 6

doi: 10.1016/j.jhep.2010.11.005

Balasubramanian B., Pogozelski W

Patients with mild, recently developed deficiency typically respond more rapidly than those who have been deficient for months or years