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Feb 1st, 2026 How Hormones Support Weight Loss and Metabolic Health Bioidentical hormone replacement therapy (BHRT) can support weight loss and metabolic health by restoring hormonal balance that influences appetite, insulin sensitivity, muscle mass, fat distribution, and resting metabolism

Biology, Mendelian randomisation, and discordance data all point in that direction, but we are not there yet with trial data

Tirzepatide (Mounjaro and Zepbound) and other GLP-1based medications require medical evaluation to determine eligibility, appropriate dosing, and safety

Future developments affecting us may not be those that we have anticipated

J.Kim SuyoungK

Whether this limited CNS penetration contributed to the trials negative outcome is unknown