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As we get older, this absorption problem compounds: the body's ability to absorb nutrients through digestion decreases progressively, and some adults become completely unable to absorb B12 orally regardless of dose

Oral vitamins must get broken down by the GI tract (through stomach, intestines) then go through the liver for metabolizing

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It depends on deficiency level and absorption

Scientific research focuses on its involvement in energy metabolism, nervous system pathways, and red blood cell formation.

Most experienced users implement cycling protocols with breaks between treatment periods as a precautionary measure, though no specific problems with extended use have been identified