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Consistent with pathology findings, DTI studies have reported the presence of more extensive WM damage in males compared with females with MS (37, 63)

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393 Other novel targets P2Y14R, a member of the purinergic receptor family, has been shown to promote the transcription of RIPK1 through the cAMP/PKA/CREB signaling axis, thereby driving necrotic apoptosis of intestinal epithelial cells and exacerbating intestinal barrier disruption and inflammatory responses