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( Regarding basal cortisol, children with PWS are generally able to produce adequate levels in daily life, as demonstrated by studies showing normal average morning basal serum cortisol ( Another issue regarding adrenal function in PWS is the presence of premature pubarche, reported in the literature with a very variable prevalence, from 14% to 60% ( 6 Bone metabolism Individuals with PWS typically have a bone structure characterized by short stature, low bone mineral density (BMD), and low bone mineral content (BMC) ( The process of bone formation is continuous throughout life, and the acquisition of bone minerals in early childhood is crucial for achieving optimal BMD levels in late adolescence

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