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doi:10.3748/wjg.v23.i48.8465

However, they play a key role in the formation and maintenance of functional BBB properties [18]

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The weight loss effect depends specifically on AMY1R and AMY3R activation, as confirmed by a study in eBioMedicine that showed cagrilintide lowers body weight through these specific receptor subtypes in the brainstem

Dosage may be reduced to 0.5 mL weekly in patients experiencing gastrointestinal intolerance or increased to a maximum of 2 mL twice weekly for short-term metabolic intensification when supervised by a qualified clinician

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