37:e142-17
There is nothing unique to GLP1s that lead to lean mass loss, we see a similar effect in dietary modifications, other medications, or bariatric surgery
Outdoor winter training, cold water access in lakes and rivers during spring and fall, and simply spending time in subzero temperatures activates similar physiological responses to dedicated cryotherapy chambers
Effects of GLP-1 RAs on Exercise Capacity It may be assumed that GLP-1 RAs could potentially increase exercise capacity primarily by promoting weight loss
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Similarly, tirzepatide, a dual GLP-1R and GIP receptor agonist, does not seem to cross the BBB efficiently (Rhea et al., 2024)