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Notably, we have revealed here that sustained intracellular GSH levels are essential for CD8 + T cell expansion, survival, and effector function and defined the complete dependence of such regulation on GPX4 expression and activity, through a metabolic signaling axis that ties the A2AR/PKA/E2F1 pathway to GSH metabolism and lipid peroxidation
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A 2026 systematic review confirmed that L-Citrulline, especially when combined with antioxidants, increases nitric oxide bioavailability and reduces oxidative stress in endothelial cells
Sample preparation Sample preparation is a key step in LC-MS/MS analysis, including methods such as protein precipitation, liquid-liquid extraction, and solid phase extraction
