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Obesity, defined as excessive fat accumulation resulting from an imbalance between energy intake (diet) and expenditure (physical activity), has reached epidemic proportions

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Potentially better lean mass preservation Slower weight loss, in general, leads to a better ratio of fat loss to lean mass loss

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Rescue of muscle endurance in LMNA (L35P) with L-carnitine treatment and in LMNA (R453W) with creatine treatment Based on our previous report, drug treatments were initiated at 28 hpf and muscle endurance was evaluated at one month of age 28 , we implemented the same experimental protocol on the three LMNA mutant transgenic fish