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DOI: 10.1038/s41392-024-01931-z, Zhu, Q., Chen, Z., Paul, P
Trials to date have focused on weight and metabolic outcomes, with lean mass reduction typically reported as a secondary endpoint and without standardized functional measures
312 showed increased muscle mitochondrial biogenesis with NR supplementation, although this was not placebo-controlled
Stiffness in the elbow , especially in the morning 4
Future studies are needed and will hopefully replicate our results, involve a larger sample size, have a control arm, and include a longer follow-up with the goal of continuing to improve MGD treatment, enhance patients quality of life, and help relieve some of the long-term healthcare burden related to ocular surface diseases in the United States
IP3 encourages the release of Ca from intracellular stores, increasing the cytosolic calcium concentration, while DAG activates protein kinase C (PKC)
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