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Glutathione, the most abundant endogenous intracellular antioxidant, plays a central role in antioxidant defenses, and irreversible cell damage supervenes when the cell is unable to maintain intracellular glutathione concentrations [41]

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Other GPCR targeted for the regulation of energy homeostasis 5-hydroxytryptamine receptor 2C (5-HT2CR) Rodent studies have demonstrated that 5-HT2CR mediates most of the food intake and body weight effects of d-fenfluramine and sibutramine, but it was withdrawn from clinical use due to increased heart rate and blood pressure (117)

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The result over consistent use is a gradual fading of existing dark spots as the skin's natural cell turnover replaces hyperpigmented surface cells, combined with reduced production of new pigmentation