In epilepsy, ketogenic dietary therapy is an established treatment, particularly for infantile, refractory, and metabolic epilepsies such as glucose transporter type 1 (GLUT1) deficiency and pyruvate dehydrogenase deficiency, where ketosis may reduce seizure frequency and severity, potentially via enhanced mitochondrial efficiency and dampened excitatory synaptic transmission, although mechanisms remain incompletely understood [67, 69, 70, 71]
However, the slight risk of increased intracerebral bleeding observed in stroke patients given ASA [79] is troubling, since MS patients have a compromised BBB [7, 8] and ASA treatment could further disrupt the BBB (Table 2)
While both are highly effective at improving body composition, they attack fat from completely different biological angles
B12 injections no weight-loss edge Studies comparing injected vs oral B12 during calorie-restricted diets found no difference in objective weight or body-composition outcomes, though the injection group sometimes reported more subjective energy
My approach: When appropriate, I use GLP-1s as ONE component of a complete strategy: Metabolic reset protocols Hormone optimization (critical for women 40+) Mediterranean nutrition principles Behavioral support systems Structured transition planning The goal isn't lifelong medication dependence
Results The baseline characteristics of the subjects in both groups were significantly matched
