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By reducing the production of these, glutamate levels lower, the consequences of oxidative stress are reduced, and pro inflammatory cytokines are reduced, reducing the effects of inflammation and oxidative stress in progressing the disease and disruption of the BBB

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Three transcription factor mutants accumulated significantly reduced amino acid content under stress, implying their function in regulating amino acid biosynthetic genes

ROS damage kidney cells by oxidizing membrane phospholipids, proteins, nucleic acids, and carbohydrates [35]