GLP-1 receptor agonists (semaglutide, tirzepatide, retatrutide) Gastrointestinal side effects dominate this class
Lawsonia intracellularis and equine proliferative enteropathy
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They never were, and framing them that way would be doing you a disservice
While such a proximal-distal loop might indeed exist, it cannot be ruled out that while fewer in number, L-cells in the upper intestine are sufficient for the rapid induction of GLP-1 secretion following nutrient intake [[316], [317], [318]]
Despite promising preclinical data, clinical translation of senotherapeutics remains hindered by SnC heterogeneity, off-target toxicity, variable efficacy across models, and lack of robust biomarkers