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Thus, the endocrine disrupting characteristic of DEHP may be one of many pathogenic mechanisms, and comprehensive of systematic studies are required to further investigate the potential mechanism of DEHP-induced BRCA

A: Definitely, yes

On the next day, targeting plasmids (sgRNA or overexpression) were co-transfected with pMD2.G (#12259, Addgene) and psPAX2 (#12260, Addgene) plasmids at 1:1:1 molar ratio using Lipofectamine 2000 (#11668019, Thermo Fisher) at 1:2.5 ratio

Continuous exposure to any signaling molecule can lead to receptor downregulation, meaning the body responds less strongly over time

PMCID: PMC7108996

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