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A 29 gauge needle produces significantly less discomfort than a 25 gauge needle and is thin enough that most patients describe the sensation as a mild pinch rather than a sting

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The strongest single piece of human evidence is Watson et al

Malaguarnera M, Vacante M, Motta M, Giordano M, Malaguarnera G, Bella R, Nunnari G, Rampello L, Pennisi G (2011) Acetyl-l-carnitine improves cognitive functions in severe hepatic encephalopathy: a randomized and controlled clinical trial