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Our respondents also thought critically about how these medications intersect with broader culture

Glucagon receptor-mediated effects introduce additional considerations: Potential for transient increases in heart rate (also observed with GLP-1R agonists) Theoretical risk of hyperglycaemia from glucagon signalling, though phase 2 trial data suggest this is counterbalanced by concurrent GLP-1R and GIPR agonism In phase 2 trials, the most commonly reported adverse events were gastrointestinal in nature, consistent with the class

However, modern research is challenging that long-held belief

Clinical trials and meta-analyses have shown that these drugs significantly improve glycemic control, reduce blood pressure, and positively impact lipid profiles, even in patients without diabetes

For some patients, continuing semaglutide close to surgery may present perioperative considerations that warrant discussion with your healthcare team