The management of painful DSPN remains less than optimal
[55] In individuals with obesity, chronic low-grade inflammation often leads to "leptin resistance"a pathological state where circulating leptin levels are high, but the brain fails to register the signal, leading to persistent hunger
In addition to its potential influence on sleep patterns, DSIP appears to influence levels of corticotropin, inhibit the production of somatostatin, reduce stress hormone secretion, maintain normal blood pressure, alter sleep patterns and also may impact pain perception
This is because starting treatment with GLP-1 medication requires titration, a process where your dosage is slowly increased each month until you reach your usual dose (called a maintenance dose)
How semaglutide works Semaglutide is a GLP-1 receptor agonist that mimics the natural GLP-1 hormone your body produces in response to eating
AOD-9604 may address exactly that problem