Ir J Med Sci 2014;183:449-53
Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)
Permeability is the property of the physical barrier specifically, but it is shaped by all four layers working together
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