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The proportion of male patients per treatment group ranged from 47% to 57% in PIONEER 1 to 5 and 8, but was greater in PIONEER 6, representing 68% to 69% of enrolled patients, as well as in PIONEER 9 and 10, where 68% to 83% of patients were male

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The composition according to any one of the preceding embodiments, wherein the composition comprises an isotonic agent being present in a concentration from 8 mg/ml_ to 50 mg/ml_, such as 14 mg/ml_ to 30 mg/ml_ of the composition