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Expression of interferon beta (IFN-), IL-1, IL-1, IL-6, IL-10, TNF-, colony-stimulating factor 2 (CSF-2), colony-stimulating factor 3 (CSF-3), chemokines CCL2 (chemokine ligand 2), and CXCL10 (C-X-C motif chemokine ligand 10), transcription factor NF-B, IB, and COX-2 are all decreased in genistein-pretreated LPS-induced RAW264.7 macrophages (103) ( Supplementary Table 1 )

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This results in mitochondrial oxidative stress and dysfunction, ultimately hepatocytes necrosis [50] (Fig