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To eliminate the need for a secondary step to remove the protease, TEV protease fused to HaloTag (HaloTEV Protease

Clinical trials have shown that Saxenda can lead to significant weight loss when used in conjunction with a reduced-calorie diet and increased physical activity

Metabolic markers showed modest improvements, with HbA1c dropping from 39.3 to 36.6 mmol/mol ( p = 0.03), but CRP levels did not significantly change [71]

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Others maintain continuous use

The models were validated through comprehensive validation procedures in Phenix