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Both vaccines are generally very safe and tolerated well, but the nasal spray can elicit more side effects

Prior Medication History: VA clinical guidelines require that you try and fail, or have a medical contraindication to, first-line generic diabetes medications (such as metformin) or other specific formulary alternatives before stepping up to a GLP-1

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Those factors should be compared on the same basis

Tirzepatide is a glucagon-like peptide-1 (GLP-1) receptor agonist for chronic weight management, along with a reduced calorie diet and increased physical activity, for people with an initial body mass index (BMI) of: 30 kg/m2 or greater (obesity) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g., hypertension, type 2 diabetes mellitus, or dyslipidemia)