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It is a structural failure of one of the most complex and poorly vascularized tissues in the human body, and that lack of blood supply is precisely what makes disc injuries so stubbornly resistant to healing

The cellular dysfunction of the brain-blood barrier from endothelial cells to astrocytes: the pathway towards neurotransmitter impairment in schizophrenia

While this association is not solely attributable to BDNF, the neurotrophin pathway is a leading mechanistic candidate

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This decline affects energy levels and overall health