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While the nephroprotective effects of SGLT2i were initially derived from secondary endpoints of CV outcome trials (CVOTs), direct confirmation came from dedicated kidney focused trials: CREDENCE (Perkovic et al NEJM 2019| NephJC Summary), DAPA-CKD (Heerspink et al NEJM 2020| NephJC Summary) and finally EMPAKIDNEY (Herrington et al NEJM 2023| NephJC Summary)

Like all medications, Semaglutide may have side effects, including nausea, vomiting, diarrhea, abdominal pain, and constipation

Common Gastrointestinal Side Effects Besides nausea, other digestive complaints frequently reported in clinical trials include: Vomiting: Often accompanies severe nausea, more common at higher doses

Our reliable semaglutide providers assess your medical history, current medications, lifestyle, and aspirations, crafting a treatment plan uniquely designed for your needs