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The two cysteine residues form a disulfide bond, creating a cyclic structure that enhances stability

Maintenance: Continue at 100 mg daily for Weeks 316 (or adjust based on response and tolerability)

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With regard to the effects of cerebellar stimulation on spasticity and other movement disorders, it is interesting that the effects are often delayed [131], just as they are in dystonic patients who are treated with pallidal interventions, suggesting that the stimulation may not only act to acutely alter synaptic transmission in brain areas downstream from the stimulation, but may lead to prominent subacute or chronic plastic changes in thalamus or cortex