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JAMA 327 , 294 (2022)

In vitro studies on 3T3-L1 cells demonstrated that the GLP-1 analog liraglutide promotes adipogenesis of pre-adipocytes, whereas it inhibits lipogenesis in mature adipocytes [71,72]

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These cells exhibit self-organizing, self-renewing and proliferative properties when cultured in an extracellular matrix (ECM) scaffold (typically Matrigel) in the presence of a specified cocktail of growth factors, in particular encompassing WNT-activating signals