Rats and mice experience obesity, dyslipidemia, glucose intolerance, insulin resistance, hyperinsulinemia, hypertension, and ANS impairment, among other hallmarks, when they reach adulthood ( Materials and Methods Animals During all experimental protocols, male Wistar rats were kept at a temperature of 23 2C, a light/dark cycle of 12 h, and had free access to water and a standard rodent chow diet (Nuvital , Curitiba, PR, Brazil)
F1000 Biology Reports , 2
USA 77 , 13651368 (1980)
Serum iron parameters, HFE C282Y genotype, and cognitive performance in older adults: results from the FACIT study
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The most prevalent form, Distal Symmetric Polyneuropathy (DSPN), results from oxidative damage to Schwann cells and sensory neurons in peripheral nerves (Panou et al., 2025)