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A mitochondria-targeted covalent organic framework (COF) prodrug that is selectively activated by high intramitochondrial GSH levels was shown to trigger catalase collapse within the organelle, thereby amplifying local chemodynamic therapy (CDT) through enhanced ROS accumulation and mitochondrial dysfunction

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Discussion VCD, characterized by an impaired ability to visually perceive and construct complex visual-spatial designs or tasks, is a well-recognized feature of aging-related neurodegenerative diseases, including Alzheimers disease 26

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Also promising is the usage of these imaging modalities in the selection of patients that may benefit from an extended time window of intravenous thrombolysis (176) and in the early detection of patients that may develop severe stroke complications such as HT, which would be key in the specific guided treatment of AIS patients avoiding, therefore, poorer prognosis and adverse clinical developments (154)

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doi:10.1016/j.nutres.2023.11.008 Tian W, Ju J, Guan B, et al

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