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Tirzepatide, a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist with rapidly growing use, has demonstrated even greater effects on glycemic control and weight loss 13,14,15

Ethical approval Ethics committee approval was not required as the data available for analysis were de-identified and not traceable back to an individual

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High levels of glucose stimulated S6K activity in both nuclei, and the presence of GLP-1 reversed such activation