Refrigerated powder can last one to two years
When lipotoxic conditions impair mitochondrial function and increase ROS production, mitophagy is upregulated as a protective response
Glutathione and GSH related enzymes such as GSH reductase, GSH peroxidases and glutathione S-transferases are fundamental parts of the antioxidant defense system in the cells to scavenge ROS and electrophilic organic molecules as well (Figure 1)
Live vaccines
Previous studies have shown that increased levels of anti-neutrophil cytoplasmic antibodies (ANCAs) in SLE patients serum suggest an impaired clearance mechanism for neutrophil debris, a significant source of self-antigens ( Apoptotic cell bodies: Lymphocytes from SLE patients frequently experience accelerated apoptosis, releasing nuclear antigens like nucleosomes into the extracellular space, which can then trigger immune responses and autoantibody formation ( Type-I IFN: Type-I IFN facilitates dendritic cell (DC) maturation, enhances autoimmune T cell survival, and activates autoantibody-producing B cells, primarily through sustained IFN- production, autophosphorylation, and activation of the IFN- receptor (IFNAR)-associated Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) ( Figure 2 4 Current and potential treatment for SLE To date, there is no definitive strategy for the treatment of SLE that can replace traditional therapies ( Figure 3 )
Stress management: Chronic stress can alter methylation dynamics
