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Paradoxically, GLP-1 agonists can cause diarrhoea as a side effect in some people despite generally slowing gut transit

Consistency is critical with tirzepatide

Week 52 benchmarks (one year) Below average: Less than 10 percent total body weight loss from baseline

Additionally, tirzepatide may directly influence lipid metabolism through GIP and GLP-1 receptor signaling in adipocytes and hepatocytes, though these mechanisms require further investigation

The onset of action for tirzepatide can vary from person to person, but it generally starts to work relatively quickly after starting the treatment

Inadequate protein accelerates muscle loss, which lowers metabolic rate and makes long-term weight maintenance harder